Description
Product Characteristics:
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).
Subcellular location: Cell membrane
Synonyms: Activin Receptor Type IIA, Activin A receptor type IIA, Activin receptor type 2A, Activin receptor type IIA, Activin receptor type-2A, ACTR 2, ACTR IIA, ACTR-IIA, ACTR2, ACTR 2, ACTR-2, ACTRII, ACTRIIA, Acvr 2, Acvr 2A, Acvr2, ACVR2A, AVR2A_HUMAN, OTTHUMP00000197918.
Target Information: The specific function of this gene has not yet been determined\, however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]